Tuesday, May 31, 2022

APOGEE MINERALS PROVIDES UPDATE ON TRANSACTION WITH ALTO VERDE COPPER

APOGEE

/NOT FOR DISTRIBUTION TO UNITED STATES NEWS SERVICES OR DISSEMINATION IN THE UNITED STATES/

VANCOUVER, British Columbia, May 30, 2022 (GLOBE NEWSWIRE) —

Apogee Minerals Ltd. (“Apogee” or the “Company”) (TSXV: APMI) announces that, further to its press releases dated January 25, 2022, and March 17, 2022, the Company has extended the time for completion of the proposed three-cornered amalgamation (the “Amalgamation”) with Alto Verde Copper Inc. (“Alto Verde”) and 1000136714 Ontario Inc. (“APMI Subco”), a wholly-owned subsidiary of the Company.

On March 17, 2022, the Company entered into a definitive agreement (the “Definitive Agreement”) with Alto Verde and APMI Subco, pursuant to which, among other things, the Company will acquire all of the issued and outstanding shares in the capital of Alto Verde (the “Transaction”).

The parties have entered into an amendment to the Definitive Agreement to extend the deadline to complete the Transaction from May 31, 2022 to July 31, 2022.

Further details regarding the Transaction and Alto Verde are disclosed in the Company’s news releases dated January 25, 2022 and March 17, 2022.

About Alto Verde:

Alto Verde Copper Inc. is a private mining company focused on its portfolio of prospective exploration assets located in the Central Volcanic Zone, within the prolific Chilean Copper belt.

Alto Verde’s portfolio includes three copper exploration projects: Pitbull in the Tarapaca Region and Tres Marias and Zenaida in the Antofagasta Region. Alto Verde holds a significant land package covering an area of 19,850 hectares with the projects situated proximal to several of the world’s largest mines.

Alto Verde’s leadership team is comprised of senior mining industry executives who have a wealth of technical and capital markets experience and a strong track record of discovering, financing, developing, and operating mining projects on a global scale. Alto Verde is committed to sustainable and responsible business activities in line with industry best practices, supportive of all stakeholders, including the local communities in which it operates.

About Apogee Minerals Ltd.:

Apogee Minerals Ltd. is a mineral exploration company. Our goal is to build shareholder value through mineral project acquisitions and advancement, as well as new mineral discoveries.

To find out more about Apogee Minerals Ltd. (TSX-V: APMI) visit the Company’s website: www.apogeemineralsltd.com

Apogee Minerals Ltd.

Jim Pettit        

James Pettit
CEO and Director

For further information, please contact:

Apogee Minerals Ltd.
Riley Trimble, Director
Email: rtrimble@sentinelmarket.com
Tel: (604) 416-2978

Alto Verde Copper Inc.
Chris Buncic, President, CEO, & Director
Email: investors@altoverdecopper.com

Completion of the Transaction is subject to a number of conditions, including but not limited to, TSXV acceptance and if applicable, disinterested shareholder approval. Where applicable, the Transaction cannot close until the required shareholder approval is obtained. There can be no assurance that the transaction will be completed as proposed or at all.

Investors are cautioned that, except as disclosed in the management information circular or filing statement to be prepared in connection with the Transaction, any information released or received with respect to the Transaction may not be accurate or complete and should not be relied upon. Trading in the securities of Apogee Minerals Ltd. should be considered highly speculative.

The TSXV has in no way passed upon the merits of the Transaction and has neither approved nor disapproved the contents of this news release.

Neither the TSXV nor its Regulation Services Provider (as that term is defined in the policies of the TSXV) accepts responsibility for the adequacy or accuracy of this news release.

Cautionary Statements Regarding Forward-Looking Information

This news release contains forward-looking information within the meaning of Canadian securities laws. Such information includes, without limitation, information regarding the structure of the Transaction, the timeline for completion of the Transaction and Alto Verde’s future exploration plans. Although the Company believes that such information is reasonable, it can give no assurance that such expectations will prove to be correct.

Forward looking information is typically identified by words such as: believe, expect, anticipate, intend, estimate, postulate and similar expressions, or are those, which, by their nature, refer to future events. The Company cautions investors that any forward-looking information provided by the Company is not a guarantee of future results or performance, and that actual results may differ materially from those in forward looking information as a result of various factors, including, but not limited to: the Companys ability to complete the Transaction; the expected timing and terms of the Transaction; the state of the financial markets for the Companys securities; the state of the natural resources sector in the event the Transaction is completed; recent market volatility and potentially negative capital raising conditions resulting from the continued COVID-19 pandemic and risks relating to the extent and duration of such pandemic and its impact on global markets; the conflict in Eastern Europe; the Companys ability to raise the necessary capital or to be fully able to implement its business strategies; and other risks and factors that the Company is unaware of at this time.

The forward-looking statements contained in this news release are made as of the date of this news release. The Company disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.

The content is by GlobeNewswire. DKODING Media is not responsible for the content provided or any links related to this content. DKODING Media is not responsible for the correctness, topicality or the quality of the content.

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Hoping Club plans to develop an immersive smart meeting room for worldwide application

Hoping

London, May 30, 2022 (GLOBE NEWSWIRE) — Hoping Club will release a new brand-new portfolio of assets and invest in a new company in Singapore to develop immersive smart meeting rooms for global application in the future.

The conference forum is a perfect blend of real space and virtual space by reconstructing the conference scenario, which allows presenters and guests in different physical geographies to be in the same virtual meeting room with realistic perspectives and senses. The smart meeting room is highly restored face-to-face communication experience.

Relying on years of experience in fund management of investment banks, Hoping Club entered the U.S. investment market and created diversified investment products for customers, with remarkable results.

After operating in the fields of stocks, funds and venture capital for two years and accumulating solid assets for Hoping Club, Hoping Club entered the real estate market in 2014. The unique trade union system of Hoping Club is not within the supervision of banks, but can play the role of banks. It provides loans, trusts, asset management, mutual fund private placement and other businesses to enterprises or individual investors, which has been welcomed by many investors. With the concerted efforts of its members, Hoping Club has helped its members earn great wealth in the recovering American real estate.

Hoping Club has a strict guild system and strict screening for members. Most of its members are top talents from all walks of life, including entrepreneurs and team leaders in sports, finance, technology, it, blockchain, digital quantification and so on. Such a team has blossomed in many places in European and American countries, Singapore, China, Malaysia and other places. The project involves financial investment, real estate, heavy metals and other fields, and has in-depth cooperation with local governments to realize the integration of guild members and society, create value, mutual benefit and win-win results.

Throughout the enterprise development process of Hoping Club, Hoping Club has been steady from the beginning, but has retained curiosity and innovation. In 2016, Hoping Club established the crypto asset investment department, which became the first organization in the world to invest in crypto assets, and won the award of “New American Investor” that year. Today, Hoping Club has expanded its territory in blockchain, Metaverse and other fields, and has become a promoter in the field of crypto digital assets.

In 2021, Hoping Club won the award of “Top 10 American Venture Capital Institution”, which may be the best recognition for him.

Hoping Club has been optimistic about the market in the Asia Pacific region in the past two years and actively launched more products related to the Asia Pacific region. However, its advantage is that the products cover the world and there are different products to meet the needs of investors. Amid the turbulence and unrest of geopolitics and the spread of the epidemic, Hoping Club continues to find new investment opportunities and explore new fields. Hoping Club will bring new surprises to its members in new fields

CONTACT:  Koby sadan
Hoping club
Hoping2012 (at) hopingclub.com

The content is by GlobeNewswire. DKODING Media is not responsible for the content provided or any links related to this content. DKODING Media is not responsible for the correctness, topicality or the quality of the content.

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THE TRAILER AND MUSIC OF “TAKAR RONG KALO” HAS BEEN LAUNCHED WITH POMP AND LUXUARY

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Pic: RAHUL KUILA

The trailer and music of “Takar Rong Kalo”, a film presented by M/s Prasanta Sahana, produced by Bilas Foundation and directed by Kalyan Sarkar, has been sunched in the Bengal Lounge with pomp and luxuary.

The cast and crew of the film along with the music team were present at the launch. Legendary singer Kumar Sanu , music director Ashok Bhadra along with Kanchan Mallick,Biswajit Chakraborty, Tanima Sen, Lovely Maitra, Amitabha Bhattacharya, Ratri Ghatak were present at the launch event.

The film is based on Sunil Chakraborty’s famous play “Takar rong Kalo”. The film speaks about an wealthy unethical businessman whose money has been stolen and that creates the hurly burly drama which surrounds the film.



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Tsuyoki Inu Making the Market More Bullish, Launched After a Booming Presale

Tsuyoki

Berlin, Germany, May 30, 2022 (GLOBE NEWSWIRE) —
 

 Tsuyoki Inu ($TINU), one of the most hyped and bullish projects on the BNB Smart Chain, with the goal of reaching unimaginable heights, was launched at 18:00 UTC May 27, 2022, after a successful presale on CookieSale.

Tsuyoki Inu presale commenced on CookieSale launchpad on May 26, 2022 at 18:00 UTC and was set for 24 hours, but the hard cap was successfully filled in the first 10 minutes of the presale. The presale had a soft cap of 100 BNB, whereas a hard cap of 200 BNB. A total of 215 contributors participated in the public presale. Further details about the presale can be found here.

Moreover, Tsuyoki Inu has also applied for a listing on CoinMarketCap, whereas the MultiChainSwap is already live on the project’s website in a collaboration with Rubic. This enables users and investors to buy Tsuyoki Inu using various currencies from various networks.

What is Tsuyoki Inu

Tsuyoki is the most anticipated and bullish project on the BNB Smart Chain, with the aim of accomplishing inconceivable heights as they embark on a Bull Run supported by a large number of well-known individuals.

Furthermore, Tsuyoki Inu plans to launch special Bull NFTs for the project with huge collection. The individuals that will mint and hold the NFTs, will be rewarded in terms of surprise prize and giveaway of more than 120 BNB, once the entire collection has been minted successfully. Along with the NFT collection, there will also be NFT marketplace, where the NFTs can be bought and sold, in the native tokens. Portions of the revenue generated from these transactions will be shared with the NFT holders as rewards, as well as to facilitate token buyback.

A lot of dollars and tactics will be put into marketing with the aid of a well-connected and experienced team, supported by a recognized marketing team, giving BSC a breath of fresh air. Tsuyoki Inu wants to build its influence on social media as it is the most powerful tool to grow and develop presence, thus attracting more investors.

Tokenomics and Taxation

$TINU is a BEP-20 token that intends to connect to multiple chains. The use of taxes is required to build and enhance the project over time. Tsuyoki Inu makes every effort to keep taxes as low as possible for investors.

The total tax on each Buy and Sell transaction is 9%, which is further divided into 3 parts:

  • 5% for marketing
  • 2% for development
  • 2% for the team

Tsuyoki Inu Contract: 0xF20753320F15C990B3Ca8f435705bB13F70357dA

BSCScan: https://bscscan.com/token/0xf20753320f15c990b3ca8f435705bb13f70357da

Tsuyoki Inu Vision

Tsuyoki is a Japanese word that means “Bullish”. With the help of a well-connected team, and a lot of influencers supporting the project, Tsuyoki Inu expects to be the only bull standing in the bear market.

Tsuyoki Inu is also working with various celebrities, crypto influencers, advertisements on crypto platforms, and press and social media marketing to help the project expand and reach new heights.

For more information about Tsuyoki Inu, visit the project’s official website and social media platforms.

About Tsuyoki Inu

Tsuyoki Inu is built on becoming a social media representative across several platforms, target groups, and celebrities. Social media, particularly Twitter, has a significant influence. This is where Tsuyoki intends to concentrate its efforts.

Furthermore, because the team is connected to many influencers and celebrities, Tsuyoki Inu will get some of the greatest communities and groups to post about the project.

Website | Telegram | Twitter

Tsuyoki Inu

info@tsuyoki-inu.com

https://tsuyoki-inu.com/

Disclaimer:

The information provided in this release is not investment advice, financial advice or trading advice. It is recommended that you practice due diligence (including consultation with a professional financial advisor before investing or trading securities and cryptocurrency.

CONTACT: Tsuyoki Inu
info (at) tsuyoki-inu.com
https://tsuyoki-inu.com/

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Kartik Aaryan Climbs On Taxi In Kolkata To Promote Bhool Bhulaiyaa 2, Sits On A Dented Roof

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By Rahul Kuila

Kartick Aaryan promotes bhool bhulaiyaa 2 in kolkata (Pic – Rahul kuila)

Kartik Aaryan is riding on the success of Bhool Bhulaiyaa 2. The film has brought relief at the Bollywood box office after a prolonged drought since The Kashmir Files. The film is all set to enter the 100 crore club this weekend. As fans waited to celebrate the milestone of his film, the actor officially released the song “ AMI JE TOMAR “ at Novotel kolkata. Then he had a visit in Howrah Bridge in Yellow Taxi….

Bhool Bhulaiyaa 2 is a fun family horror-comedy of all time that one shouldn’t miss out on! Directed by Anees Bazmee, Bhool Bhulaiyaa 2, produced by Bhushan Kumar, Murad Khetani, Anjum Khetani, and Krishan Kumar under the banner of T-Series and Cine 1 Studios. Watch the family entertainer, NOW IN CINEMAS!



from https://www.thetimesofbengal.com/international/kartik-aaryan-climbs-on-taxi-in-kolkata-to-promote-bhool-bhulaiyaa-2-sits-on-a-dented-roof/
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Kasba Girl Death | Kolkata News: 18 year old girl Body Recovered in Kasba Area

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#Kolkata: Unusual death of a young woman again in the city after Pallabi Bidisha Manjusha. The body of 18-year-old Saraswati Das was found hanging from her house at midnight on Saturday. According to police, Saraswati has committed suicide.

Preliminary investigations revealed that Saraswati lived with her mother, aunt and grandmother in a house in Kasba, South Kolkata. Ayr worked for both his mother and aunt. Both of them were on night duty on Saturday. Saraswati was with her grandmother at home. After eating at night, both of them went to bed. Saraswati was talking on the phone with someone in bed like other nights. Probably talking a little excited, claims his sister. However, as it happens occasionally, his old grandmother fell asleep thinking it was normal like other days.

When she woke up at night, Saraswati’s grandmother saw her hanging in the next room. Saraswati’s body was frozen by the time the rest of them arrived, even though they managed to get her down by cutting the noose.

Read more: The question is surrounding the unusual death of a young woman in Kasba! Is exhaustion consuming the young women of the city?

In the aftermath of the incident, the police of Kasba police station lodged a complaint of unusual death. However, no complaint was lodged against anyone on behalf of the family. His body was autopsied on Sunday. The police will be able to know the whole matter in the autopsy report. The aunt of the deceased girl claimed that their daughter was probably having an affair with a boy, or that someone was harassing her. But what happened that forced Saraswati to take this extreme decision, they do not understand.

Read more: Saraswati after Vidisha-Manjusha? The young woman’s hanging body was rescued in the city! Mystery is growing around death

Saraswati loved to take pictures, she was always smiling, her mother could not imagine how this girl could have happened. Saraswati thanked her mother for inspiring her for the rest of her life. Although they have not made any complaint against anyone, all the family members are looking at the report of the police investigation.

Sahnik Ghosh

Published by:Sanjukta Sarkar

First published:

Tags: Girl death, Kolkata News



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Bandel Station: Passengers are having trouble due to sudden interruption in Train Service | Canceled one train after another! Nityayatirera extreme suffering, when will the solution? | kolkata

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Horoscope

The year will go well Work may be a little stressful, but it will be a good year There may be a gathering of guests in the family Give yourself a little time this year

Keep a cool head in the new year There may be some problem in the office This new year can be a conversation with a new person

Look at the body in the new year You can get pain in stomach pain New job opportunities may come Keep an eye on expenses

In the new year, there is the addition of love, affection and marriage Give yourself a little time You can go somewhere in front with the family

The office environment will be good in the new year If you can, talk less Stay away from secret enemies New job opportunities may come

In the new year, an old friend can come back to life This week has been fruitful for traders Students can expect good results

You can suffer from lack of confidence in the new year Meditate to get peace of mind. 3 Try to keep yourself away from immoral things.

Keep an eye on the body in the new year May suffer from cold, cough The time is good for teachers

In the new year, there is the addition of promotion in the workplace You can get involved in a dispute with a person who is the mother of the family

In the new year, you will get name, fame, prestige, all these today. Your mental and physical condition will remain positive this week.

If you are looking forward to a pleasant change in the new year, this week will be a great opportunity. You will have special interest in creative subjects like art, dance, literature, etc. The monotonous daily life will become lively. Enjoy meeting loved ones. The day is also good for the students. Hard work will not fail. Get great success at work. There is a possibility of financial gain.

Keep your eyes and ears open in the new year Beware of secret enemies You can buy a new house or car There may be a gathering of guests in the house





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Another girl found dead in Kasba Area Police on investigation | The question is surrounding the unusual death of a young woman in Kasba! Exhaustion is consuming the girls of the city? – News18 Bangla

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#Kolkata: The body of a young woman was found hanging in Kolkata. After Pallavi, Bidisha, Manjusha, this time Saraswati Das. The shocking incident took place in Bediadanga Second Lane in Kasba Thana area. According to police sources, the tragic incident took place on Saturday night. It is learned that Saraswati Mysterious Death was recovered by the police of Kasba Police Station (Saraswati Mysterious Death) on Sunday morning.

The family claims that Saraswati was the make-up artist. Mehndi also used to work as an artist. As well as tuition. Loved taking pictures. But what is the reason for such a fate of a young woman of only nineteen years today? What happened that made him decide to end his life? Or is there some other reason behind this death?

Read more: Saraswati after Vidisha-Manjusha? The young woman’s hanging body was rescued in the city! Mystery is growing around death

According to police sources, no suicide note was found. What causes death? Depression? Was there a relationship? The police will also look into whether any relationship is strained. Dida lived at her uncle’s house in Kasbat and Swaraswati Das lived with her mother. The family claimed that he was talking on the phone last night because one of his relatives called him while the other cut off the phone and picked up the relative’s phone. In that case, the family members are not sure if there was a relationship with anyone.

Saraswati Das Saraswati Das

Why are so many young women choosing the path of suicide again and again? What are the reasons behind it? In the last few days, the untimely death of the model actress has shaken the minds of the people of Kolkata. This has also caused a storm of discussion on social media. Families are also worried about the tension in the relationship.

Read more: Suddenly go to the kitchen … Random knife! Harhim incident at Haridebpur de-addiction center

It is to be mentioned that the hanging body of actress Pallavi was first recovered in Garfa in just a couple of weeks ago. Then the hanging body of model Bidisha was recovered in Nagerbazar. Two days later, the hanging body of Manjusha Niyogi was recovered in Patuli in a very similar manner. And this time Swaraswati Das. City dwellers are shocked by the deaths of four young women in a row. On the other hand, Saraswati’s family claimed that a notebook was found in her house in which Saraswati had written some words for her mother. He also wrote that his mother has always been an inspiration and thanked him. Mom and Aunt Ayre work. As a result, no one was at home except Dida on Saturday. The shadow of mourning in the incident is also among the neighbors from the family. Kasba police have started investigation by filing an unusual death case in the whole matter.

Arpita Hajra

Published by:Sanjukta Sarkar

First published:

Tags: Dead Body Found, Girl Suicide, Kolkata News



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Sunday, May 29, 2022

SSC: Time in hand and 11 days, new twist in SSC corruption investigation! What’s going to happen next …

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#Kolkata: New twist in CBI probe into SSC corruption. Subsequent summons of CBI investigators to Nizam Palace. On Monday, the CBI summoned two accused, Anindita Bera and Sabina Yasmin. The central agency is seeking documents from two cases of ninth-tenth grade teacher recruitment corruption and non-teaching staff recruitment corruption. In the next 10 days, the CBI has summoned Babita Sarkar, one of the plaintiffs in the case of appointment of Minister Paresh Adhikari’s daughter.

Babita has been summoned within 8-10 days as Siliguri is home. The CBI started summoning the plaintiffs in compliance with the CRPC. The CBI is speeding up the mystery of recruitment corruption through the School Service Commission. 11 days in hand. In the meantime, the progress report of the investigation has to be submitted to the bench of Justice Abhijit Gangopadhyay. The CBI is reluctant to waste any time before submitting the report on June 10.

Read more: Everyone saw a little while ago, the man from Baguio finished everything as soon as he entered the flat! Wife in the background?

আইনজীবীরা Lawyers say it is important to summon the plaintiffs in the CBI investigation. According to lawyer Sudipta Dasgupta, lawyer Firdaus Shamim, Vikram Bandopadhyay, so far CBI interrogation, attendance has all been under the direct direction of the High Court. The CBI interrogation has gained more recognition as the division bench has strengthened the hand of the single bench. Former Education Minister Perth Chatterjee has filed a special leave petition in the Supreme Court. The SLP has not yet been accepted in the apex court due to procedural flaws.

Read more: Real beat Liverpool to win the Champions League again, incredible thing happened in the final!

In this situation, the CBI is trying to build an investigation by recording the documents of illegal recruitment. Out of the total 6 CBI investigations, 2 CBI investigations were directed into Group D recruitment corruption. The two plaintiffs are Sandeep Kumar Prasad and Lakshmi Tunga. Justice Abhijit Gangopadhyay directed the CBI probe. According to the report of Justice Bug Committee, 609 illegal appointments have been made. 15 appointments have been made by submitting blank OMR sheets. OMR sheet assessment agency has been changed without board meeting. The CBI directed the appointment of Group C in the case of Justice Abhijit Gangopadhyay Sabina Yasmin. The Bug Committee’s investigation report revealed 361 illegal appointments. Of these, 222 jobs without sitting for exams and 180 qualified jobs in the high jump formula. The Bug Committee’s report reveals the equivalence of vacancies and recruitment recommendation positions.

It is alleged that Bengali teachers have been recruited from outside the merit list. Allegation of employing high jump formula in history in Setabuddin case. CBI probe into English teacher recruitment corruption in Anindita Berar case. Abdul Gani Ansari case: CBI probe into math teacher recruitment corruption. A single bench of the high court also observed that SSKM could not take advantage of Woodburn in the case, directing the then education minister Perth Chatterjee to face the CBI. ডি Following the CBI directive, the division bench withdrew the stay order and upheld the path of justice shown by Justice Abhijit Ganguly. ভবিষ্য A division bench of Justices Subrata Talukder and Anand Mukherjee decides the future of the CBI probe order.

The only CBI probe into the appointment of class XI-XII teachers is in Babita Sarkar’s case Ankita Adhikari, daughter of state minister for education Paresh Adhikari, has been accused of illegal recruitment in the case. Sources said that the CBI would issue a notice in accordance with Section 91 of the Criminal Procedure Code seeking documents from all the plaintiffs. The biggest challenge now facing the CBI is to find the documents for the appointment of assistant teachers from the plaintiffs and to find out the corruption in the appointment of teachers. There is no recommendation of any inquiry committee for appointment of teachers of ninth-tenth, eleventh-twelfth classes. The CBI has to find out the criminal offense.

Published by:Suman Biswas

First published:

Tags: Calcutta High Court, CBI, SSC



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Kolkata News: Everybody saw it a little while ago, the person from Baguiat finished everything after entering the flat! Wife in the background?

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#Kolkata: Unusual death again. This time Ashwini Nagar of Baguia. The deceased was identified as Sadananda Das, aged 51 years. Ophthalmologist by profession. Sadanandababu’s hanging body was recovered from his flat in Baguio shortly after 9pm on Saturday. Baguiati police are investigating the incident.

The initial guess of the police is that the person named Sadananda Das may have committed suicide due to a family dispute. Sadananda Das lived with his wife and one and a half year old son in a flat in Ashwini Nagar, Baguia. Sadananda Babu, an ophthalmologist by profession, has an eyeglass shop in the area. Even though he was a happy person, the neighbors claimed that there was a constant quarrel with his wife Mahua Layek Das in the family. Sadananda Das’s wife was often in trouble.

Read more: 36 minutes late start! Benazir’s incident in the Champions League final, because you will be shocked to hear

Did Sadananda Das, an ophthalmologist by profession, choose the path of suicide because of him? A neighbor of the deceased Sadananda Babu said that he met Sadananda Babu shortly before 9 pm on Saturday. After a while, I heard a couple of sounds in the flat, as if the door was being broken. After a while, the six-and-a-half-year-old boy came out of the flat crying. That’s when it became known that such a tragic accident had taken place.

Read more: Real beat Liverpool to win the Champions League again, incredible thing happened in the final!

Then the news was given to Baguiati police station. Police recovered the body and took it to a local hospital, where doctors declared Sadananda Das dead. Neighbors further said that there was a constant quarrel between husband Sadananda and wife Mahua. What is the consequence of that incident! However, they could not say anything clearly about that. However, the initial guess of the Baguiat police is that the incident may have happened due to a family dispute. An autopsy will be conducted at RGK Medical College Hospital on Sunday. If necessary, Mahua Layek Das, wife of the late Sadananda Das, will also be questioned, police said.

— Government of Onkar

Published by:Suman Biswas

First published:

Tags: Kolkata News, Suicide



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West Bengal Weather Update: What is the forecast for last Sunday’s heavy change in weather? Rain in some districts?

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West Bengal Weather Update: According to sources, a total of 3 people were injured in today’s storm. 2 children, one 6 years old and the other 12. Another 35-year-old man was hit in the head. The three were taken to the National Medical College Hospital where they were released after receiving first aid.



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FROM BOGOTÁ TO MONACO, COLOMBIAN MURALIST MAKES HIS MARK ON ONE OF THE WORLD’S MOST EXCLUSIVE CANVASES WITH VUSE

FROM

VUSE AND THE McLAREN F1 TEAM’S DRIVEN BY CHANGE INITIATIVE SECURES NEXT OPPORTUNITY FOR UNDERREPRESENTED ARTIST DURING FORMULA 1 GRAND PRIX™ DE MONACO 2022

MONACO, May 28, 2022 /PRNewswire/ — An emerging Colombian muralist has been given one of the world’s most exclusive canvases to bring to life his work in real-time in Monaco, over the FORMULA 1 GRAND PRIX™ DE MONACO 2022 weekend.

Vuse, the number one global vape brand**, and partner McLaren F1 Team, have today unveiled a mural, created by an artist from Bogotá, Columbia, at one of the most exclusive races in the world, on the Monaco beachfront at the Grimaldi Forum. The mural marks the latest activity as part of the Driven by Change programme, which offers underrepresented creative talent around the globe the opportunity to showcase their passion and work on one of the world’s biggest and most high-profile stages – elite motorsport.

The artist, DAST, is a 38-year-old Colombian muralist who was chosen to create the artwork in Monaco because of his passion for art which has driven his creative pursuits for the past ten years. As a Bogota native, DAST is surrounded by a wealth of inspiration including the diverse geographies and rich heritage of Colombia – something completely opposite to the usual glitz and glamour seen along the Monaco beachfront. These elements inspire DAST to step out of his comfort zone and create murals that explore the relationships between people, places, and spaces.

DAST’s gritty artwork and bold persona have been expertly captured in this live mural, which beautifully juxtaposes with the classical, shiny Monaco cityscape. Chosen for his unique style, embracing geometric shapes, colours, and the relationships that occur in public spaces between buildings, streets and pedestrians to inspire and inform the abstract mural. Featuring DAST’s signature geometric composition, the mural, which DAST painted in real-time, has been inspired by themes of speed, combined with the aerodynamic design of McLaren F1 Team’s car and the vibrant papaya and blue colourway. 

DAST, Freelance Artist, comments: “I have been pursuing a career in art and design for over 10 years and opportunities like this are few and far between. When I first started creating my designs, in my home in Bogotá, I never would have thought that one day I would have the opportunity to live my dream of becoming a full-time artist. Having my work showcased at one of the most exclusive Grand Prix™  races and painting the mural in real-time on a beautiful canvas such as Monaco’s beachfront makes the opportunity even more special!”

“These last six months have been truly life-changing. It is an honour to be one of the creatives involved in Vuse’s Driven by Change initiative and I hope to see more creatives like me, take part in this incredible opportunity showcasing their work, passions and values on the global platform of motorsports.”

Driven by Change premiered in December 2021 at the FORMULA 1 ETIHAD AIRWAYS ABU DHABI GRAND PRIX™ 2021, where McLaren unveiled a one-off livery designed by Arabic artist, Rabab Tantawy, celebrating the first time a female artist from the Middle East had been given this kind of opportunity. This year, Driven by Change officially started at the Miami Grand Prix™ where US photographer, Jonathan Walker, captured content around the streets of Miami and at the circuit. Jonathan worked alongside McLaren’s digital content team, gaining valuable experiences, industry contacts and skills.

John Beasley, Group Head of Brand Building, BAT, comments: “We are really proud of the opportunities the Driven by Change initiative has already provided to emerging creatives such as Rabab Tantawy Jonathan Walker, and now DAST! It is great to see DAST’s raw passion, grit, geometric style and unique vision come to life on a completely juxtaposing canvas such as the Monaco beachfront. Our activity with Driven by Change showcases how Vuse is committed to making the dreams of emerging artists a reality.”

The initiative forms part of Vuse’s ongoing ambition to accelerate creative pursuits of underrepresented creative talent across the globe, working with McLaren to identify opportunities to bring their work to life, helping introduce creatives from diverse backgrounds to the masses. DAST’s artwork will be showcased for one night only, on Saturday 28th at the Grimaldi Forum, ahead of the FORMULA 1 GRAND PRIX™ DE MONACO 2022 on Sunday 29th of May.

Rabab Tantawy comments: “I could never have imagined the opportunity that Driven by Change offered me. To become the first artist to have an original piece of art racing on-track was one of the most incredible things to happen in my career. The opportunity truly changed my life. I am excited to be involved in Driven by Change this year, working alongside Vuse and McLaren to continue to change the lives of underrepresented artists, like myself.”

Launching in August, creatives worldwide will have the opportunity to apply to be selected for future Driven by Change opportunities, including showcasing work at an upcoming Grand Prix™, to once-in-a-lifetime exclusive collaborations with The McLaren F1 Team. Specific opportunities, dates and timings for submission will be announced soon.

To discover more about DAST’s story, visit Vuse and DAST’s social channels. Further information on the Driven by Change initiative and how creatives can get involved in these once-in-a-lifetime opportunities will be shared later in the year.

Notes to Editors:

About BAT

BAT is a leading, multi-category consumer goods business with a purpose to build A Better Tomorrow by reducing the health impact of its business through offering a greater choice of enjoyable and less risky products for adult consumers. The company continues to be clear that combustible cigarettes pose serious health risks, and the only way to avoid these risks is not to start or to quit. BAT encourages those who would otherwise continue to smoke to switch completely to scientifically-substantiated, reduced-risk alternatives*. In order to deliver this, BAT is transforming into a truly consumer-centric multi-category consumer products business. BAT employs over 53,000 people and operates in over 180 countries, with 11 million points of sale and 45 factories in 43 markets. The company’s Strategic Portfolio is made up of its global cigarette brands and a growing range of reduced-risk* New Category tobacco and nicotine products and traditional non-combustible tobacco products. These include vapour, tobacco heating products, modern oral products including tobacco-free nicotine pouches, as well as traditional oral products such as snus and moist snuff. In 2020, we had 13.5 million consumers of our non-combustible products, a rise of 3 million on the year before. The BAT Group generated revenue of £25.8 billion in 2020 and profit from operations of £9.9 billion.

*Based on the weight of evidence and assuming a complete switch from cigarette smoking. These products are not risk free and are addictive.

** Based on Vype/Vuse estimated value share from RRP in measured retail for vapour (i.e. total vapour category value in retail sales) in the USA, Canada, France, UK, Germany. These 5 markets cover an estimated 77% of global vapour closed system NTO, calculated in June –July 2021.

About McLaren Racing

McLaren Racing was founded by New Zealand racing driver Bruce McLaren in 1963. The team entered its first Formula 1 race in 1966, since then McLaren has won 20 Formula 1 world championships, more than 180 Formula 1 grands prix, the Le Mans 24 Hours at its first attempt and the Indianapolis 500 three times. McLaren Racing currently competes in Formula 1 globally and INDYCAR in the US. 

The team is contesting the 2021 FIA Formula 1 World Championship with Lando Norris and Daniel Ricciardo, and in the 2021 INDYCAR Series with Arrow McLaren SP drivers Pato O’Ward and Felix Rosenqvist. McLaren was the first F1 team to be certified carbon neutral ten years ago and has successfully retained the Carbon Trust Standard Award, most recently in February 2021. They were also the first team to be awarded the FIA Institute’s Environmental Award in 2013, which they have consistently maintained at three-star level.

In 2022, McLaren Racing will enter a new category of motorsport when it enters a team into Extreme E, the innovative all-electric off-road racing series that highlights the impact of climate change.

About Rabab Tantawy

Born in 1971 in Cairo Rabab Tantawy grew up watching her mother draw and create. Although she did not pursue an artistic career from the get-go, Rabab always kept an interest in the arts and taught herself different techniques, ranging from very traditional mediums like oil painting to modern ones like spray-paints.

When Tantawy decided to dedicate herself to the arts she got involved in several exhibitions while also actively pursuing street art.

Working with a multitude of mediums the artist created a playful approach to the otherwise serious concepts that ground her work. Her biggest focus is on union, community, and heritage.

While often we can see artists approach these subjects from a political point of view, Rabab tries to bridge the gap and render these subjects through the lens of universality.

Rabab is an intuitive artist. She doesn’t work with preliminary sketches; she uses the canvas as a support for direct download. There’s no expectation for a final product. In a way the product is the process of creation itself.

Line and colour are the pillars of Tantawy’s work. Be it abstract or figurative the artist’s work starts from line. The lines function as a skeleton, informing the whole process of the artwork in the making. Be it soft flowing lines or strong angular ones, this step sets the rhythm of the work. While a lot of artists are choosing to work with limited colour palettes, Tantawy switches from classical earthy colours to strong neon colours in the same series with the same ease she switches between mediums.

Photo – https://mma.prnewswire.com/media/1828164/Vuse.jpg

 


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Kolkata Police: Veterans drowning in exhaustion, Kolkata Police trying to make a fresh start with ‘Belashuru’

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#Kolkata: Loneliness is growing in the city. Depression is now spreading like a contagion from house to house. Loneliness is on the rise, sometimes leading to death.

Most of the residents of the educated society are now suffering from mental depression. Towards the end of his life, many residents of the city are suffering from loneliness and mental depression. Part of the elderly living in TBHK flats in the city leaving their children for work or personal reasons.

During the coronation period, their depression increased due to various reasons. Life under house arrest is very different from this society. Joy from social gatherings, nothing was possible for a section of the elderly people of Tilottama.

Read more- Many big decisions about rowing clubs, new rules are coming right after the accident

The elders were seen in the auditorium of the bodyguard line of Kolkata police on Saturday afternoon. After passing the Corona episode, the elders entered the cinema hall for the first time on Saturday afternoon. It can be said that after the beginning of the movie, you started watching movies.

Many of the city’s elders try to keep themselves busy to forget loneliness. Atul Singh said, you have to be alone, it is true, but I do not want to be alone through work. I will watch a movie again after Corona. Mudhurima Sen said, “I was trying to remember the last time I saw a movie with so many people.” We are really alone at night.

Feeling feudal said, this initiative is really good. Just thinking about being alone. All the instructors from the Belashuru crew were present in the auditorium of Kolkata Police on Saturday. Besides praising the initiative of showing the movie in this way, Shivprasad Mukherjee, the director of Belashuru, advised the elders to move away from depression by showing movies in the neighborhood as before.

Read more- Expensive living, did not have income, Vidisha was involved in debt? Feeling the demands

Kolkata Police Commissioner Binit Goel said the initiative was a way to keep the elderly away from loneliness and mental exhaustion. Attempts have been made to explain through this seminar that this is how it can be started.

Published by:Suman Majumder

First published:

Tags: Belashuru, Kolkata Police



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Heavy rains with thunderstorms in Kolkata and adjoining areas, as well as strong winds – News18 Bangla

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Along with the rain, there has also been lightning Today, the temperature in Kolkata and other districts of South Bengal was 6 তাপ C throughout the day It was unbearably hot with him



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Saturday, May 28, 2022

Global Tech Industries Group, Inc. gives further instructions to shareholders regarding its digital dividend.

Global

New York, NY, May 27, 2022 (GLOBE NEWSWIRE) — Global Tech Industries Group, Inc. (OTCQB: GTII) (“GTII” or the “Company”), www.gtii-us.com, a Nevada corporation, announced today that it has further instructions for its shareholders, as of the record date of May 9, 2022, who want to accept ownership of their digital dividends in the form of Shibu Inu tokens.

Once Liberty Stock Transfer, Inc., the company’s transfer agent, has compiled the complete list of shareholders requesting their digital tokens, it will send the list to www.beyondblockchain.us. If the shareholder has an account there, the tokens will automatically be deposited into their digital wallet. If the shareholder does not have an account there, they can go on the www.beyondblockchain.us website and open an account and the tokens will be deposited into their new accounts. If a shareholder has a digital wallet on another digital platform, such as Coinbase, or wishes to open an account on another digital platform to receive their tokens, they should go to the www.beyondblockchain.us website where they will receive instructions on how to transfer the tokens to the digital platform of their choice, as long as the platform trades in ERC20 tokens.

GTII continues to urge its shareholders to go to the company’s website, www.gtii-us.com, access the token request form, and send it into the company’s transfer agent, Liberty Stock Transfer, Inc. at inbox@libertystocktransfer.comShareholders will not be eligible to receive their tokens until they fill in and send a request form.

About Global Tech Industries Group, Inc.: GTII is a publicly traded Company incorporated in the state of Nevada, specializing in the pursuit of acquiring new and innovative technologies. Visit GTII here https://gtii-us.com/.

Please follow our Company at: www.otcmarkets.com/stock/GTII or at https://gtii-us.com/

Safe Harbor Forward-Looking Statements:
This press release may contain forward looking statements that are based on current expectations, forecasts, and assumptions that involve risks as well as uncertainties that could cause actual outcomes and results to differ materially from those anticipated or expected, including statements related to the amount and timing of expected revenues related to our financial performance, expected income, distributions, and future growth for upcoming quarterly and annual periods. These risks and uncertainties are further defined in filings and reports by the Company with the U.S. Securities and Exchange Commission (SEC). Actual results and the timing of certain events could differ materially from those projected in or contemplated by the forward-looking statements due to a number of factors detailed from time to time in our filings with the SEC. Among other matters, the Company may not be able to sustain growth or achieve profitability based upon many factors including but not limited to the risk that we will not be able to find and acquire businesses and assets that will enable us to become profitable. Reference is hereby made to cautionary statements set forth in the Company’s most recent SEC filings. We have incurred and will continue to incur significant expenses in our development stage, noting that there is no assurance that we will generate enough revenues to offset those costs in both the near and long term. New lines of business may expose us to additional legal and regulatory costs and unknown exposure(s), the impact of which cannot be predicted at this time.

Words such as “estimate,” “project,” “predict,” “will,” “would,” “should,” “could,” “may,” “might,” “anticipate,” “plan,” “intend,” “believe,” “expect,” “aim,” “goal,” “target,” “objective,” “likely” or similar expressions that convey the prospective nature of events or outcomes generally indicate forward-looking statements. You should not place undue reliance on these forward-looking statements, which speak only as of this press release. Unless legally required, we undertake no obligation to update, modify or withdraw any forward-looking statements, because of new information, future events or otherwise.

Global Tech Industries Group, Inc.
511 Sixth Avenue, Suite 800
New York, NY 10011
Info@gtii-us.com

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several children of gardenrich and metiabruz area affected by chicken pox – News18 Bangla

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#Kolkata: In the city of Kolkata, more than one child was infected with chicken pox at the same time and was admitted to Beleghata ID Hospital. But is chicken pox returning to Kolkata? Concerned health department of Kolkata Municipality. The Calcutta Municipality will launch a special awareness next week.

Most of the children infected with chicken pox and measles are from Gardenrich-Metiaburuj area. Every Wednesday, children are vaccinated at the Kolkata Municipal Health Center. Reluctance to get vaccinated is increasing in this area. Deputy Mayor of Kolkata Atin Ghosh expressed concern over the growing reluctance not only to vaccinate against measles but also against polio.

The municipality will launch a special awareness campaign next Thursday. Earlier also, Kolkata Municipality had achieved results by conducting social awareness campaign on polio vaccination. Atin Ghosh, deputy mayor of Kolkata and acting mayor of the health department, said: This area is the seat of Mayor Firhad Hakim’s own assembly. Next Thursday, the mayor himself and officials of the health department of Calcutta Municipality will be present. Awareness will be spread in that area. The importance of vaccination against various viral diseases, including chicken pox, will be emphasized.

Atin Ghosh added, “Several children in the area have been infected with polio before. Awareness was spread at that time. Even at that time, the polio vaccine was found in Hatena. This time Calcutta Municipality is going to walk that path. The Kolkata Municipality is going to take a special awareness campaign next Thursday, June 2.

BISWAJIT SAHA

Published by:Rukmini Mazumder

First published:

Tags: Chicken Pox



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NANO MAGIC SELLS MAJORITY INTEREST IN APPLIED NANOTECH TO EMPLOYEES AND ELECTS DAVID SHERBIN TO BOARD

NANO

MADISON HEIGHTS, Mich., May 27, 2022 (GLOBE NEWSWIRE) — Nano Magic Holdings, Inc. (OTCMKT: NMGX) (“Nano Magic” or the “Company”), a leader in nanotechnology-powered cleaning, protection and anti-fog solutions announced that effective at the end of the month it is selling a majority interest in Applied Nanotech, Inc. (“Applied Nanotech”) to the employees of that subsidiary.

Jacque Soptick, an employee for over 20 years, became the majority owner of Applied Nanotech. She stated: “We are excited for this new chapter of Applied Nanotech as a woman-owned business. After more than two decades, the time has finally arrived to take ownership of its future.” Dr. Richard Fink, the other purchaser who is continuing as the chief scientist explained: “After decades of commitment to Applied Nanotech, Jacque and I can now call it our own. I look forward to continuing my collaboration with Jacque to expand and grow the contract research and specialized product sales, capitalizing on our technology.” For Nano Magic, Tom Berman, President, noted: “This lets Nano Magic sharpen its focus on brand development and our own product portfolio while still retaining minority ownership in Applied Nanotech and its future. This is a true win-win transaction.”

On May 26, 2022 David Sherbin was elected to the Nano Magic board. Mr. Sherbin retired in April 2021from from his position as the senior vice president, general counsel, chief compliance officer and secretary at Aptiv PLC (formerly Delphi Automotive). He joined that company in 2005 and served as General counsel & Chief Compliance Officer. Prior to that, Mr. Sherbin served Pulte Group, Federal Mogul Corporation and Heller Financial Inc. in legal and compliance roles. He is a graduate of Oberlin College and Cornell Law School. He is 62 years old. Tom Berman commented: “We are elated to have someone of David’s caliber and experience join our Board. He has worked virtually his entire career with public reporting companies and brings to our Board a wealth of legal, business, and compliance experience that will strengthen our team.”

About Nano Magic

Nano Magic is a leader in developing and bringing to market cutting-edge nanotechnology-powered industrial and consumer cleaning, protection and anti-fog solutions formulated in Detroit, Michigan. Nano Magic focuses on innovative and advanced product solutions harnessing the magic power of nanotechnology to create a safer, more socially conscious, and higher performing world. Visit www.nanomagic.com for more information.

Safe Harbor Statement 

This press release contains forward-looking statements within the meaning of applicable securities laws that involve risks and uncertainties, many of which are outside of our control, concerning our business, products, and financial results. Actual results may differ materially from the results expressed or implied by forward-looking statements. In some cases, you can identify forward-looking statements by our use of words such as “expect,” “anticipate,” “will,” “believe,” and similar expressions. Forward-looking statements are necessarily based upon estimates and assumptions that are inherently uncertain. All statements are made as of the date of this release, and we undertake no obligation to update publicly any of these forward-looking statements to reflect actual results or new information except as required by applicable laws. More information about our business, products, and financial results are included in our annual report on Form 10-K for the fiscal year ended December 31, 2021, and in reports subsequently filed by us with the Securities and Exchange Commission (“SEC”).

All documents are available through the SEC’s Electronic Data Gathering Analysis and Retrieval System (EDGAR) at www.sec.gov or from our website listed above. All forward-looking statements apply only as of the date hereof. We hereby disclaim any obligation to publicly update the information provided above, including forward-looking statements, to reflect subsequent events or circumstances, except as required by law.

Contact Information

Nano Magic Holdings Inc.
Jeanne Rickert
j.rickert@nanomagic.com
(844) 273-6462

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minor boy death in kolkata shrouded in mystery – News18 Bangla

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#Kolkata: Doubts over the death of a minor student were raised among family members. Allegedly, the father of the deceased himself has a hand in death! And so before the cremation, the police of Netajinagar police station in South Kolkata sent the body from Keoratala crematorium to the morgue of SSKM for autopsy. Exactly what caused the death of the minor, will be understood only after the autopsy report.

Snehanshu Sengupta, 18, a resident of Nakatala, died on Friday. On the 11th, Snehanshu was admitted to MR Bangur Hospital in critical condition. As his condition continued to deteriorate, he was shifted to Chittaranjan Hospital on the 20th. Snehanshur died today. After this, Pistuto Didi Indrani Gupta Mukherjee complained that the father had ‘killed’ the boy with an overdose of drugs! When a complaint was lodged at Netajinagar police station, the body was sent from the crematorium to the morgue. There will be an autopsy tomorrow.

Snehanshu’s Pistuto Didi Indrani Gupta Mukherjee alleged, “Snehanshu’s father Shishir Kumar Sengupta got remarried and abused his son a lot.” The arrow of accusation is towards Shishir Kumar Sengupta, his counter-allegation is that sister Indrani wanted to take her son. Nana would give advice, as a result the boy would cause great unrest in the house.

According to family sources, Shishirbabu is not currently associated with any profession. In the past, he worked as a manager in a private company in Saudi Arabia. His first wife died in 2014. He later got married for the second time. Snehanshu’s sister Sriparna said that after her mother died, two brothers and sisters lived in PC’s house for two years. Didi claims that everything that Indrani is complaining about her brother’s death is ‘false’. Sriparna also said that in those two years, her father sent 22,000 rupees to PC from abroad. But Sriparna claims that the PC used to tell them that the father did not send any money.

Police officials said the next step would be taken on the basis of the final report of the autopsy.

SHANKU SANTRA

Published by:Rukmini Mazumder

First published:

Tags: Student death



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Bidisha Dey: Bidisha’s friend Anubhav was interrogated, what questions came up during the interrogation, watch the video. Video: Bidisha Dey Death: Bidisha Deys friend Anubhav has been questioned | kolkata

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Horoscope

The year will go well Work may be a little stressful, but it will be a good year There may be a gathering of guests in the family Give yourself a little time this year

Keep a cool head in the new year There may be some problem in the office This new year can be a conversation with a new person

Look at the body in the new year You can get pain in stomach pain New job opportunities may come Keep an eye on expenses

In the new year, there is the addition of love, affection and marriage Give yourself a little time You can go somewhere in front with the family

The office environment will be good in the new year If you can, talk less Stay away from secret enemies New job opportunities may come

In the new year, an old friend can come back to life This week has been fruitful for traders Students can expect good results

You can suffer from lack of confidence in the new year Meditate to get peace of mind. 3 Try to keep yourself away from immoral things.

Keep an eye on the body in the new year May suffer from cold, cough The time is good for teachers

In the new year, there is the addition of promotion in the workplace You can get involved in a dispute with a person who is the mother of the family

In the new year, you will get name, fame, prestige, all these today. Your mental and physical condition will remain positive this week.

If you are looking forward to a pleasant change in the new year, this week will be a great opportunity. You will have special interest in creative subjects like art, dance, literature, etc. The monotonous daily life will become lively. Enjoy meeting loved ones. The day is also good for the students. Hard work will not fail. Get great success at work. There is a possibility of financial gain.

Keep your eyes and ears open in the new year Beware of secret enemies You can buy a new house or car There may be a gathering of guests in the house





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Friday, May 27, 2022

Onconova Therapeutics Announces Abstract at the ASCO Annual Meeting Highlighting Narazaciclib’s Differentiated Inhibitory and Improved Safety Profile in Preclinical Models

Onconova

In vitro and cell-based assays suggest narazaciclib’s inhibitory profile may provide safety and efficacy advantages over currently approved CDK4/6 inhibitors

NEWTOWN, Pa., May 26, 2022 (GLOBE NEWSWIRE) — Onconova Therapeutics, Inc. (NASDAQ: ONTX), a clinical-stage biopharmaceutical company focused on discovering and developing novel products for patients with cancer, today announced the publication of an abstract at the American Society of Clinical Oncology (ASCO) Annual Meeting. Featured in the abstract are preclinical data from in vitro and cell-based assays that demonstrate how narazaciclib’s inhibitory profile differentiates it from the FDA-approved CDK4/6 inhibitors palbociclib, ribociclib, and abemaciclib.

Key data and conclusions from the abstract include:

  • Narazaciclib, abemaciclib, palbociclib, and ribociclib each have strong affinity for CDK4/cyclin D1, with Kd values of 0.18 nM, 0.08 nM, 0.75 nM, and 1.3 nM, respectively.
  • Narazaciclib and abemaciclib have similar affinities against CDK family members, including nM activity against CDK2/cyclin A, which may play a role in resistance to palbociclib and ribociclib.
  • Narazaciclib’s inhibitory activity against GSK3β, a kinase whose inhibition putatively causes tolerability issues related to diarrhea, is ~29 times less than that of abemaciclib.
  • Cellular kinase assays showed narazaciclib’s highest inhibitory activity to be against CDK4/6, CSF1R, (supports pro-tumor immune suppression), and NUAK1/ARK 5 (associated with poor prognosis in multiple cancers and implicated in cancer cell migration, invasion, and metastasis).
  • Cellular Thermal Shift Assay (CETSA) and integrative Inferred Kinase Activity (INKA) analysis showed that narazaciclib is associated with and modulated unique signaling pathways resulting in specific deregulated phosphorylation patterns when compared to palbociclib treated cells.

Steven M. Fruchtman, M.D., President and Chief Executive Officer of Onconova and co-author of the abstract, commented, “Though revolutionary and commercially successful, currently available CDK4/6 inhibitors are limited by tolerability and safety issues as well as the unfortunate reality of primary and acquired drug resistance. This creates a pressing unmet need for novel agents that may overcome these shortcomings and provide patients with durable clinical benefit. Narazaciclib’s decreased affinity for targets associated with poor tolerability, together with its increased inhibitory activity against kinases implicated in metastasis, cancer cell survival, immune suppression, and drug resistance, suggests it may address this need. We continue to explore this hypothesis in narazaciclib’s clinical program and remain on track to establish a recommended Phase 2 dose by the end of the year.”

A copy of the abstract, titled, “Narazaciclib’s kinase inhibitory activity is differentiated from approved CDK4/6 inhibitors in preclinical models,” is available on the ASCO Annual Meeting website.

About Onconova Therapeutics

Onconova Therapeutics is a clinical-stage biopharmaceutical company focused on discovering and developing novel products for patients with cancer. The Company has proprietary targeted anti-cancer agents designed to disrupt specific cellular pathways that are important for cancer cell proliferation.

Onconova’s novel, proprietary multi-kinase inhibitor narazaciclib (formerly ON 123300) is being evaluated in two separate and complementary Phase 1 dose-escalation and expansion studies. These trials are currently underway in the United States and China.

Onconova’s product candidate rigosertib is being studied in an investigator-sponsored study program, including in a dose-escalation and expansion Phase 1/2a investigator-sponsored study with oral rigosertib in combination with nivolumab for patients with KRAS+ non-small cell lung cancer.

For more information, please visit www.onconova.com.

Forward-Looking Statements

Some of the statements in this release are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995, and involve risks and uncertainties. These statements relate to Onconova’s expectations regarding the timing of Onconova’s and investigator-initiated clinical development and data presentation plans, and the mechanisms and indications for Onconova’s product candidates. Onconova has attempted to identify forward-looking statements by terminology including “believes,” “estimates,” “anticipates,” “expects,” “plans,” “intends,” “may,” “could,” “might,” “will,” “should,” “preliminary,” “encouraging,” “approximately” or other words that convey uncertainty of future events or outcomes. Although Onconova believes that the expectations reflected in such forward-looking statements are reasonable as of the date made, expectations may prove to have been materially different from the results expressed or implied by such forward-looking statements. These statements are only predictions and involve known and unknown risks, uncertainties, and other factors, including the success and timing of Onconova’s clinical trials, investigator-initiated trials and regulatory agency and institutional review board approvals of protocols, Onconova’s collaborations, market conditions and those discussed under the heading “Risk Factors” in Onconova’s most recent Annual Report on Form 10-K and quarterly reports on Form 10-Q. Any forward-looking statements contained in this release speak only as of its date. Onconova undertakes no obligation to update any forward-looking statements contained in this release to reflect events or circumstances occurring after its date or to reflect the occurrence of unanticipated events.

Company Contact:
Avi Oler
Onconova Therapeutics, Inc.
267-759-3680
ir@onconova.us
https://www.onconova.com/contact/

Investor Contact:
Bruce Mackle
LifeSci Advisors, LLC
646-889-1200
bmackle@lifesciadvisors.com

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